Background:

Human Papillomavirus (HPV) vaccination uptake remains low in Nigeria despite its potential to prevent cervical cancer. Limited understanding exists regarding public perceptions and barriers to HPV vaccine acceptance. This study aimed to analyze public discussions about HPV and HPV vaccines in Nigeria to identify misinformation patterns, knowledge gaps, and community concerns that influence vaccine uptake.

Methods:

Social listening, an innovative digital surveillance tool, was employed to monitor HPV related conversations from August 1-14, 2025. Data was collected using Determ software across multiple platforms including X (formerly Twitter), Facebook, YouTube, and web articles. A total of 881 HPV related conversations were captured and analysed for themes, sentiment, reach, and engagement patterns. Risk matrix, categorized misinformation, knowledge gap, questions, and concerns on HPV into high risk, moderate risk and low risk based on reach, engagement, virality and potential to cause harm.